Lipopolysaccharide-Induced Toxicity

Diosgenin prevents microglial activation and protects dopaminergic neurons from lipopolysaccharide-induced neural damage.

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PMID: Int J Mol Sci. 2021 Sep 26; 22 (19). Epub 2021 Sep 26. PMID: 34638697 Abstract Title: Diosgenin Prevents Microglial Activation and Protects Dopaminergic Neurons from Lipopolysaccharide-Induced Neural Damage In Vitro and In Vivo. Abstract: BACKGROUND: The prevention of age-related neurodegenerative disorders is an important issue in an aging society. Microglia-mediated neuroinflammation resulting in … Read more

Ginsenoside Rb1 alleviates bleomycin-induced pulmonary inflammation and fibrosis.

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PMID: Drug Des Devel Ther. 2022; 16: 1793-1809. Epub 2022 Jun 13. PMID: 35719213 Abstract Title: Ginsenoside Rb1 Alleviates Bleomycin-Induced Pulmonary Inflammation and Fibrosis by Suppressing Central Nucleotide-Binding Oligomerization-, Leucine-Rich Repeat-, and Pyrin Domains-Containing Protein Three Inflamome Act Pathway. Abstract: Purpose: Idiopathic pulmonary fibrosis is a chronic and irreversible fibrotic interstitial pneumonia of unknown etiology … Read more

Cannabinoids alleviate the lipopolysaccharide-induced cytokine storm.

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PMID: Cells. 2022 Apr 20; 11 (9). Epub 2022 Apr 20. PMID: 35563697 Abstract Title: Cannabinoids Alleviate the LPS-Induced Cytokine Storm via Attenuating NLRP3 Inflammasome Signaling and TYK2-Mediated STAT3 Signaling Pathways In Vitro. Abstract: Cannabinoids, mainly cannabidiol (CBD) andΔ-tetrahydrocannabinol (THC), are the most studied group of compounds obtained from because of their several pharmaceutical properties. … Read more

Evidence for anti-inflammatory effects and modulation of neurotransmitter metabolism by Salvia officinalis L.

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PMID: BMC Complement Med Ther. 2022 May 12; 22 (1): 131. Epub 2022 May 12. PMID: 35550086 Abstract Title: Evidence for anti-inflammatory effects and modulation of neurotransmitter metabolism by Salvia officinalis L. Abstract: BACKGROUND: Cognitive health is of great interest to society, with neuroinflammation and systemic inflammation age-related risk factors. that are linked to declines … Read more

Electroacupuncture alleviates LPS-induced ARDS through α7 nicotinic acetylcholine receptor-mediated inhibition of ferroptosis.

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PMID: Front Immunol. 2022; 13: 832432. Epub 2022 Feb 10. PMID: 35222419 Abstract Title: Electroacupuncture Alleviates LPS-Induced ARDS Throughα7 Nicotinic Acetylcholine Receptor-Mediated Inhibition of Ferroptosis. Abstract: Acute respiratory distress syndrome (ARDS) is an uncontrollable, progressive pulmonary inflammatory disease, and as a common clinical critical disease, there is no effective treatment available. Electroacupuncture (EA) therapy is … Read more

Ginsenoside Rg1 inhibits microglia pyroptosis induced by lipopolysaccharide.

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PMID: J Inflamm Res. 2021; 14: 6619-6632. Epub 2021 Dec 7. PMID: 34908862 Abstract Title: Ginsenoside Rg1 Inhibits Microglia Pyroptosis Induced by Lipopolysaccharide Through Regulating STAT3 Signaling. Abstract: Purpose: Neuroinflammation runs through the whole process of nervous system diseases and brain injury. Inflammasomes are thought to be particularly relevant to immune homeostasis, and their dysregulation … Read more