Ginsenosides

Ginsenoside Rb1 inhibits astrocyte activation and promotes the transfer of astrocytic mitochondria to neurons against ischemic stroke.

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PMID: Redox Biol. 2022 Jun 8; 54: 102363. Epub 2022 Jun 8. PMID: 35696763 Abstract Title: Ginsenoside Rb1 inhibits astrocyte activation and promotes the transfer of astrocytic mitochondria to neurons against ischemic stroke. Abstract: Astrocytes activation in response to stroke results in altered mitochondrial exchange with neurons. Ginsenoside Rb1is a major ginsenoside of Panax ginseng … Read more

Ginsenoside Rb1 alleviates bleomycin-induced pulmonary inflammation and fibrosis.

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PMID: Drug Des Devel Ther. 2022; 16: 1793-1809. Epub 2022 Jun 13. PMID: 35719213 Abstract Title: Ginsenoside Rb1 Alleviates Bleomycin-Induced Pulmonary Inflammation and Fibrosis by Suppressing Central Nucleotide-Binding Oligomerization-, Leucine-Rich Repeat-, and Pyrin Domains-Containing Protein Three Inflamome Act Pathway. Abstract: Purpose: Idiopathic pulmonary fibrosis is a chronic and irreversible fibrotic interstitial pneumonia of unknown etiology … Read more

Ginsenoside Rg1 protects mice against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced liver injury.

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PMID: J Ethnopharmacol. 2022 May 17; 294: 115394. Epub 2022 May 17. PMID: 35595219 Abstract Title: Ginsenoside Rg1 protects mice against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced liver injury by inhibiting CYP1A1 through the aryl hydrocarbon receptor. Abstract: ETHNOPHARMACOLOGICAL RELEVANCE: Panax ginseng CA Meyer (ginseng) is a widely used traditional Chinese medicine that has played a beneficial role in the … Read more

Ginsenoside Rg1 attenuates the inflammation and oxidative stress induced by diabetic nephropathy.

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PMID: Ann Transl Med. 2021 Dec; 9 (24): 1789. PMID: 35071483 Abstract Title: Ginsenoside Rg1 attenuates the inflammation and oxidative stress induced by diabetic nephropathy through regulating the PI3K / AKT / FOXO3 pathway. Abstract: Background: Diabetic nephropathy (DN) is one of the most common microvascular complications in diabetes mellitus. Ginsenoside Rg1 (Rg1) is an … Read more

Ginsenoside Rg1 inhibits microglia pyroptosis induced by lipopolysaccharide.

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PMID: J Inflamm Res. 2021; 14: 6619-6632. Epub 2021 Dec 7. PMID: 34908862 Abstract Title: Ginsenoside Rg1 Inhibits Microglia Pyroptosis Induced by Lipopolysaccharide Through Regulating STAT3 Signaling. Abstract: Purpose: Neuroinflammation runs through the whole process of nervous system diseases and brain injury. Inflammasomes are thought to be particularly relevant to immune homeostasis, and their dysregulation … Read more

Ginsenoside Rg3 inhibits osteosarcoma progression by reducing circ_0003074 expression in a miR-516b-5p / KPNA4-dependent manner.

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PMID: J Orthop Surg Res. 2021 Dec 20; 16 (1): 724. Epub 2021 Dec 20. PMID: 34930332 Abstract Title: Ginsenoside Rg3 inhibits osteosarcoma progression by reducing circ_0003074 expression in a miR-516b-5p / KPNA4-dependent manner. Abstract: BACKGROUND: Previous data have suggested that ginsenoside Rg3 (Rg3), isolated from the roots of Panax ginseng, plays a repressing role … Read more

Ginsenoside Rg1 exerts anti ‑ apoptotic effects on non ‑ alcoholic fatty liver cells by downregulating the expression of SGPL1.

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PMID: Mol Med Rep. 2022 05; 25 (5). Epub 2022 Mar 24. PMID: 35322862 Abstract Title: Ginsenoside Rg1 exerts anti ‑ apoptotic effects on non ‑ alcoholic fatty liver cells by downregulating the expression of SGPL1. Abstract: Non ‑ alcoholic fatty liver disease (NAFLD) has a high incidence, and can lead to liver cirrhosis and … Read more