Betulinic acid improves cardiac-renal dysfunction caused by hypertrophy.

PMID: Nutrients. 2021 Sep 30; 13 (10). Epub 2021 Sep 30. PMID: 34684485 Abstract Title: Betulinic Acid Improves Cardiac-Renal Dysfunction Caused by Hypertrophy through Calcineurin-NFATc3 Signaling. Abstract: Cardiac hypertrophy can lead to congestive heart failure and is a leading cause of morbidity and mortality worldwide. In recent years, it has been essential to find the … Read more

Betulinic acid prevents liver fibrosis by binding Lck and suppressing Lck in HSC activation and proliferation.

PMID: J Ethnopharmacol. 2022 Jun 15; 296: 115459. Epub 2022 Jun 15. PMID: 35714879 Abstract Title: Betulinic acid prevents liver fibrosis by binding Lck and suppressing Lck in HSC activation and proliferation. Abstract: ETHNOPHARMACOLOGICAL RELEVANCE: Hypericum japonicum Thunb. ex Murray (Hypericaceae), named ‘Tianjihuang’ is a traditional Chinese medicine with hepatoprotective, antibacterial, and antitumor effects. Betulinic … Read more

Betulinic acid accelerates diabetic wound healing by modulating hyperglycemia-induced oxidative stress, inflammation and glucose intolerance.

PMID: Burns Trauma. 2022; 10: tkac007. Epub 2022 Apr 9. PMID: 35415192 Abstract Title: Betulinic acid accelerates diabetic wound healing by modulating hyperglycemia-induced oxidative stress, inflammation and glucose intolerance. Abstract: Background: Diabetes significantly delays wound healing through oxidative stress, inflammation and impaired re-epithelialization that lead to defective regulation of the healing process, although the related … Read more