Astragaloside Ⅳ alleviates ulcerative colitis by regulating the balance of Th17 / Treg cells.

PMID: Phytomedicine. 2022 Jun 19; 104: 154287. Epub 2022 Jun 19. PMID: 35752072 Abstract Title: AstragalosideⅣ alleviates ulcerative colitis by regulating the balance of Th17 / Treg cells. Abstract: BACKGROUND: Restoring immune homeostasis by targeting the Th17 / Treg response is a potentially valuable therapeutic strategy for ulcerative colitis (UC). Astragaloside IV (AS-Ⅳ) is a … Read more

Astragaloside IV ameliorates pulmonary vascular remodeling in hypoxia-induced pulmonary hypertension.

PMID: Phytomedicine. 2022 May 23; 102: 154171. Epub 2022 May 23. PMID: 35636165 Abstract Title: Astragaloside IV ameliorates pulmonary vascular remodeling in hypoxia-induced pulmonary hypertension by restraining the T follicular helper cell response and expanding T follicular regulatory cell response. Abstract: BACKGROUND: Pulmonary hypertension (PH) is a progressive disorder lacking a validated and effective therapy … Read more

Astragaloside A protects against photoreceptor degeneration.

PMID: J Inflamm Res. 2022; 15: 2995-3020. Epub 2022 May 20. PMID: 35645574 Abstract Title: Astragaloside A Protects Against Photoreceptor Degeneration in Part Through Suppressing Oxidative Stress and DNA Damage-Induced Necroptosis and Inflammation in the Retina. Abstract: Purpose: Photoreceptors are specialized retinal neurons responsible for phototransduction. Loss of photoreceptors directly leads to irreversible vision impairment. … Read more

Hepatoprotective effects of astragaloside IV and formononetin against oxidative injury.

PMID: FASEB J. 2022 May; 36 Suppl 1. PMID: 35554062 Abstract Title: Hepatoprotective Effects of Astragaloside IV and Formononetin Against Oxidative Injury. Abstract: The mitochondrial SIRT3 is a major deacetylase protein that regulates important mitochondrial biology, including metabolic pathways, reactive oxygen species detoxification, mitochondrial dynamics, and the mitochondrial unfolded protein response. We found that astragalus … Read more

Astragaloside IV inhibits the progression of liver cancer.

PMID: Am J Transl Res. 2022; 14 (3): 1551-1566. Epub 2022 Mar 15. PMID: 35422920 Abstract Title: Astragaloside IV inhibits the progression of liver cancer by modulating macrophage polarization through the TLR4 / NF-/B / STAT3 signaling pathway. Abstract: AIM: The purpose of the present research was to investigate the effect and mechanism of Astragaloside … Read more