Anti-Fibrotic

Tanshinone IIA regulates the TGF-/1 / Smad signaling pathway to ameliorate non-alcoholic steatohepatitis-related fibrosis.

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PMID: Exp Ther Med. 2022 Jul; 24 (1): 486. Epub 2022 Jun 1. PMID: 35761808 Abstract Title: Tanshinone IIA regulates the TGF-/1 / Smad signaling pathway to ameliorate non-alcoholic steatohepatitis-related fibrosis. Abstract: Tanshinone IIA (TIIA) is a major component extracted from the traditional herbal medicineand has been indicated to play a role in the treatment … Read more

Betulinic acid prevents liver fibrosis by binding Lck and suppressing Lck in HSC activation and proliferation.

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PMID: J Ethnopharmacol. 2022 Jun 15; 296: 115459. Epub 2022 Jun 15. PMID: 35714879 Abstract Title: Betulinic acid prevents liver fibrosis by binding Lck and suppressing Lck in HSC activation and proliferation. Abstract: ETHNOPHARMACOLOGICAL RELEVANCE: Hypericum japonicum Thunb. ex Murray (Hypericaceae), named ‘Tianjihuang’ is a traditional Chinese medicine with hepatoprotective, antibacterial, and antitumor effects. Betulinic … Read more

Ginsenoside Rb1 alleviates bleomycin-induced pulmonary inflammation and fibrosis.

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PMID: Drug Des Devel Ther. 2022; 16: 1793-1809. Epub 2022 Jun 13. PMID: 35719213 Abstract Title: Ginsenoside Rb1 Alleviates Bleomycin-Induced Pulmonary Inflammation and Fibrosis by Suppressing Central Nucleotide-Binding Oligomerization-, Leucine-Rich Repeat-, and Pyrin Domains-Containing Protein Three Inflamome Act Pathway. Abstract: Purpose: Idiopathic pulmonary fibrosis is a chronic and irreversible fibrotic interstitial pneumonia of unknown etiology … Read more

Zerumbone rescues cardiac function by attenuating cardiac fibrosis.

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PMID: Phytomedicine. 2022 Jun; 100: 154078. Epub 2022 Mar 31. PMID: 35405613 Abstract Title: Zerumbone, a humulane sesquiterpene from Syringa pinnatifolia, attenuates cardiac fibrosis by inhibiting of the TGF-/1 / Smad signaling pathway after myocardial infarction in mice. Abstract: BACKGROUND: Zerumbone (ZER) is a humulane sesquiterpene isolated from Syringa pinnatifolia Hemsl., A representative Mongolian herbal … Read more

Exploring the mechanism whereby sinensetin delays the progression of pulmonary fibrosis.

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PMID: Front Pharmacol. 2021; 12: 693061. Epub 2021 Jun 18. PMID: 34220517 Abstract Title: Exploring the Mechanism Whereby Sinensetin Delays the Progression of Pulmonary Fibrosis Based on Network Pharmacology and Pulmonary Fibrosis Models. Abstract: The incidence of pulmonary fibrosis (PF), a progressively fatal disease, has increased in recent years. However, there are no effective medicines … Read more

Icariin improves renal interstitial fibrosis in a rat model of chronic renal failure.

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PMID: Zhongguo Zhong Yao Za Zhi. 2022 Apr; 47 (8): 2170-2177. PMID: 35531733 Abstract Title: [Icariin improves renal interstitial fibrosis in a rat model of chronic renal failure by regulating mitochondrial dynamics]. Abstract: This study aims to explore the effect of icariin (ICA) on mitochondrial dynamics in a rat model of chronic renal failure (CRF) … Read more

Cordyceps cicadae ameliorates renal hypertensive injury and fibrosis.

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PMID: Front Pharmacol. 2021; 12: 801094. Epub 2022 Feb 10. PMID: 35222012 Abstract Title: Ameliorates Renal Hypertensive Injury and Fibrosis Through the Regulation of SIRT1-Mediated Autophagy. Abstract: Hypertensive renal injury is a complication of hypertension. () Is a traditional Chinese medicine used to treat chronic kidney diseases especially renal fibrosis. Autophagy is described as a … Read more

The ameliorative effects of arctiin and arctigenin on the oxidative injury of lung induced by silica.

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PMID: Oxid Med Cell Longev. 2021; 2021: 5598980. Epub 2021 Jul 17. PMID: 34336106 Abstract Title: The Ameliorative Effects of Arctiin and Arctigenin on the Oxidative Injury of Lung Induced by Silica via TLR-4 / NLRP3 / TGF-Signaling Pathway. Abstract: Silicosis remains one of the most serious diseases worldwide, with no effective drug for its … Read more