Emodin targeting the colonic metabolism via PPARγ alleviates ulcerative colitis by inhibiting facultative anaerobe.

PMID: Phytomedicine. 2022 May 27; 104: 154106. Epub 2022 May 27. PMID: 35728384 Abstract Title: Emodin targeting the colonic metabolism via PPARγ alleviates UC by inhibiting facultative anaerobe. Abstract: BACKGROUND: Emodin is an active ingredient of traditional Chinese medicine Rheum palmatum L. and Polygonum cuspidatum, which possesses anti-inflammatory and intestinal mucosal protection effects. Our previous … Read more

Astragaloside Ⅳ alleviates ulcerative colitis by regulating the balance of Th17 / Treg cells.

PMID: Phytomedicine. 2022 Jun 19; 104: 154287. Epub 2022 Jun 19. PMID: 35752072 Abstract Title: AstragalosideⅣ alleviates ulcerative colitis by regulating the balance of Th17 / Treg cells. Abstract: BACKGROUND: Restoring immune homeostasis by targeting the Th17 / Treg response is a potentially valuable therapeutic strategy for ulcerative colitis (UC). Astragaloside IV (AS-Ⅳ) is a … Read more

Ginsenoside Rb1 alleviates bleomycin-induced pulmonary inflammation and fibrosis.

PMID: Drug Des Devel Ther. 2022; 16: 1793-1809. Epub 2022 Jun 13. PMID: 35719213 Abstract Title: Ginsenoside Rb1 Alleviates Bleomycin-Induced Pulmonary Inflammation and Fibrosis by Suppressing Central Nucleotide-Binding Oligomerization-, Leucine-Rich Repeat-, and Pyrin Domains-Containing Protein Three Inflamome Act Pathway. Abstract: Purpose: Idiopathic pulmonary fibrosis is a chronic and irreversible fibrotic interstitial pneumonia of unknown etiology … Read more

Echinacoside alleviates acetaminophen-induced liver injury.

PMID: J Appl Biomed. 2021 05; 19 (2): 105-112. Epub 2021 Apr 26. PMID: 34907710 Abstract Title: Echinacoside alleviates acetaminophen-induced liver injury by attenuating oxidative stress and inflammatory cytokines in mice. Abstract: This study evaluates the protective effect of Echinacoside on acute liver toxicity induced by acetaminophen in mice and the mechanism behind it. Echinacoside … Read more

Berberine regulates short-chain fatty acid metabolism and alleviates the colitis-associated colorectal tumorigenesis through remodeling intestinal flora.

PMID: Phytomedicine. 2022 May 27; 102: 154217. Epub 2022 May 27. PMID: 35660350 Abstract Title: Berberine regulates short-chain fatty acid metabolism and alleviates the colitis-associated colorectal tumorigenesis through remodeling intestinal flora. Abstract: BACKGROUND: Colitis-associated cancer (CAC) is known to be a complex combination of tumor cells, non-tumor cells and a large intestinal flora. The increasing … Read more

Fucoidan alleviates renal fibrosis in diabetic kidney disease.

PMID: Front Pharmacol. 2022; 13: 790937. Epub 2022 Mar 18. PMID: 35370636 Abstract Title: Fucoidan Alleviates Renal Fibrosis in Diabetic Kidney DiseaseInhibition of NLRP3 Inflammasome-Mediated Podocyte Pyroptosis. Abstract: Fucoidan (FPS) has been widely used to treat renal fibrosis (RF) in patients with diabetic kidney disease (DKD); however, the precise therapeutic mechanisms remain unclear. Recently, research … Read more

Electroacupuncture alleviates LPS-induced ARDS through α7 nicotinic acetylcholine receptor-mediated inhibition of ferroptosis.

PMID: Front Immunol. 2022; 13: 832432. Epub 2022 Feb 10. PMID: 35222419 Abstract Title: Electroacupuncture Alleviates LPS-Induced ARDS Throughα7 Nicotinic Acetylcholine Receptor-Mediated Inhibition of Ferroptosis. Abstract: Acute respiratory distress syndrome (ARDS) is an uncontrollable, progressive pulmonary inflammatory disease, and as a common clinical critical disease, there is no effective treatment available. Electroacupuncture (EA) therapy is … Read more

Berberine alleviates NLRP3 inflammasome induced endothelial junction dysfunction.

PMID: Phytomedicine. 2022 Apr 26; 101: 154131. Epub 2022 Apr 26. PMID: 35533609 Abstract Title: Berberine alleviates NLRP3 inflammasome induced endothelial junction dysfunction through Casignalling in inflammatory vascular injury. Abstract: BACKGROUND: Berberine has received rising attention for its application in cardiovascular disease because of its relationship with inflammation. The endothelial NLRP3 inflammasome triggers inflammatory vascular … Read more

Dl-3-n-butylphthalide alleviates behavioral and cognitive symptoms via modulating mitochondrial dynamics in the A53T-α-synuclein mouse model of Parkinson’s disease.

PMID: Front Neurosci. 2021; 15: 647266. Epub 2021 May 28. PMID: 34121985 Abstract Title: Dl-3-n-Butylphthalide Alleviates Behavioral and Cognitive Symptoms Via Modulating Mitochondrial Dynamics in the A53T-α-Synuclein Mouse Model of Parkinson’s Disease. Abstract: BACKGROUND: Aggregation and neurotoxicity of the presynaptic proteinα-synuclein and the progressive loss of nigral dopaminergic neurons are believed to be the key … Read more

Puerarin alleviates depression-like behavior induced by high-fat diet combined with chronic unpredictable mild stress.

PMID: Front Pharmacol. 2021; 12: 767333. Epub 2021 Dec 15. PMID: 34975477 Abstract Title: Puerarin Alleviates Depression-Like Behavior Induced by High-Fat Diet Combined With Chronic Unpredictable Mild StressRepairing TLR4-Induced Inflammatory Damages and Phospholipid Metabolism Disorders. Abstract: Puerarin has been reported as a potential agent for neuro-inflammatory disorders. However, there have been no reports of using … Read more